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Journal of Tropical Pediatrics 2001 47(5):284-287; doi:10.1093/tropej/47.5.284
© 2001 by Oxford University Press
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Oxidative Stress is Not Enhanced in Non-malnourished Infants with Persistent Diarrhea

E. Granot1, M. Binsztok1, D. Fraser1, R. J. Deckelbaum1 and Z. Weizman1

1 Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beersheva, Israel

Increased concentrations of reactive oxygen species (ROS) and depleted antioxidant defences have been implicated in a cycle of infection, malabsorption and malnutrition, leading to persistent diarrhea. In order to determine whether in non-malnourished children oxidative stress predisposes to the development of persistent diarrhea, infants with acute diarrhea (< 7 days) (n = 39) were compared to infants with persistent diarrhea (> 14 days) (n = 38). Lipid peroxidation was assessed by the TBARs assay and expressed as malondialdehyde equivalent content (nmol MDA/ml plasma), and levels of plasma antioxidants vitamin A and vitamin E were determined. In infants with acute and persistent diarrhea nutritional status, as assessed by weight/height and height-for-age, hemoglobin levels, serum albumin and immunoglobulin levels, did not differ between groups. Serum vitamin A and vitamin E levels did not differ in infants with acute or persistent diarrhea. TBARs, expressed as nmol MDA/ml plasma did not differ between infants with acute or persistent diarrhea and furthermore did not differ from levels in a healthy, similar age, control group. Non-malnourished infants with persistent diarrhea do not exhibit plasma antioxidant depletion or enhanced lipid peroxidation. In these infants, oxidative stress, as reflected in plasma, does not play a role in the pathogenesis of persistent diarrhea.


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