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Journal of Tropical Pediatrics 2001 47(1):39-45; doi:10.1093/tropej/47.1.39
© 2001 by Oxford University Press
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Vitamin E administration and reversal of neurological deficits in protein-energy malnutrition

V KalraA,D, JK GroverB, GK AhujaC, S RathiA, S GulatiA and N KalraD

A Department of Pediatrics, B Pharmacology, and C Neurology, All India Institute of Medical Sciences, New Delhi, India D Pt. B. D. Sharma Medical College, Rohtak, India

Neurological signs including posterior columns, spinocerebellar, retinal, and peripheral nerve deficits are being increasingly recognized in vitamin E deficiency states. Children suffering from protein-energy malnutrition (PEM) revealed significantly reduced serum {alpha}-tocopherol levels compared to age-matched normal children, the deficient subjects also exhibited the widely recognized signs of tocopherol deficiency. In this prospective therapeutic intervention study moderate PEM subjects were administered aqueous oral vitamin E supplementation for 6 weeks and compared with control PEM subjects. The parameters studied included pre- and post-therapy serum {alpha}-tocopherol levels (p<0.001), {alpha}-tocopherol lipid ratio (p<0.001), reduced creatine phosphokinase levels (p<0.01), and reduced neurological signs in PEM subjects (p<0.001). The observed improvement in neurological dysfunction among PEM subjects is of great interest, especially in developing countries. While larger studies are recommended, the importance of vitamin E administration in PEM is being reported.


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