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Journal of Tropical Pediatrics 2000 46(1):15-20; doi:10.1093/tropej/46.1.15
© 2000 by Oxford University Press
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The role of expressed breastmilk and continuous positive airway pressure as predictors of survival in extremely low birthweight infants

N-Y BooA,Z, C-H PuahA and M-S LyeB

A Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Tenteram, 56000 Kuala Lumpur, Malaysia B Department of Epidemiology and Biostatistics, Institute of Medical Research, Kuala Lumpur, Malaysia Z Corresponding author

A case-control study was carried out on 152 extremely low birthweight (ELBW, <1000 g) infants born consecutively in a large Malaysian maternity hospital during a 21-month period to determine the significant predictors associated with survival at discharge. Forty-nine (32.2 per cent) of these infants survived and 103 (67.8 per cent) died. The survivors weighed significantly heavier (mean=888 g, SD=99) than infants who died (mean=763 g, SD=131; p<0.0001). They were also of higher gestational age (mean=28.7 weeks, SD=2.2), than those who died (mean=26.7 weeks, SD=2.5; P<0.0001). Logistic regression analysis showed that, after controlling for various confounders, only three factors were significantly associated with the survival of these infants. These were: (1) increasing birthweight of the infants (with every gram increase in birthweight, adjusted odds ratio of survival was: 1.009; 95 per cent CI 1.004, 1.015; p=0.0006); (2) given nasal continuous positive airway pressure for treatment of respiratory distress syndrome (adjusted odds ratio of survival: 4.2; 95 per cent CI 1.2, 14.0; p=0.02); and (3) given expressed breastmilk (adjusted odds ratio of survival: 57.5; 95 per cent CI: 7, 474; p=0.0002). Maternal illness, intrapartum problems, ethnicity, gestational age, use of antenatal steroid, modes of delivery, Apgar scores, congenital anomalies, respiratory distress syndrome, persistent ductus arteriosus, septicemia, necrotising enterocolitis, chronic lung disease, oxygen therapy, intermittent positive pressure ventilation, surfactant therapy, and blood transfusion were not significant factors associated with increased survival.


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