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Journal of Tropical Pediatrics 1998 44(5):291-295; doi:10.1093/tropej/44.5.291
© 1998 by Oxford University Press
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Vitamin E Deficiency and Associated Neurological Deficits in Children with Protein-energy Malnutrition

V. Kalra*,, J. Grover**, G. K. Ahuja***, S. Rathi* and D. S. Khurana*

*Department of Pediatrics, All India Institute of Medical Sciences New Delhi, India
**Department of Pharmacology, All India Institute of Medical Sciences New Delhi, India
***Department of Neurology, All India Institute of Medical Science New Delhi, India

V. Kalra, Additional Professor of Pediatrics, All India Institute of Medical Sciences, New Delhi-110029, India. Fax 0091 11 6862663

Vitamin E is important in maintaining normal neurological structure and function. In this study, 100 children with protein-energy malnutrition (PEM) were studied and compared to a suitably agematched control group. Posterior column deficits, cerebellar deficits, and problems with fine motor coordination were present to a significant degree in the PEM subjects. The presence of neurological signs was correlated with various parameters of vitamin E deficiency, including low serum {alpha} tocopherol levels and a low tocopherol/total lipid ratio which was present in 92 per cent of subjects. There was good concordance between vitamin E levels and vitamin E to serum lipid ratio in assessing vitamin E deficiency. We conclude that vitamin E deficiency is prevalent, to a hitherto unsuspected degree, in children with PEM and that these malnourished children have significant neurological deficits attributable to low vitamin E levels. This observation is of clinical significance as the neurological deficits are potentially reversible with vitamin E supplementation.


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