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Journal of Tropical Pediatrics 1998 44(3):165-166; doi:10.1093/tropej/44.3.165
© 1998 by Oxford University Press
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brief-report

Effect of Levamisole on the Immune Status of Malnourished Children

M. Shiva Prakash*,, Veera Mohan Rao** and Vinodini Reddy***

*National Institute of Nutrition, Indian Council of Medical Research Jamai Osmania, Hyderabad - 500 007, India
** 5–58 Vykota, V/A Ananthrajpeta, Cuddapah District, Andhra Pradesh, India
***National Institute of Nutrition (ICMR) Jamai Osmania PO, Hyderabad, India

Dr M. Shiva Prakash, address as above. Tel. 00 91 40 701 8909; Fax 00 91 40 701 9074. E-mail: icmmin{at}ren.nic.in

Levamisole is known to enhance an impaired immune response. Its function as an immunostimulant was assessed in malnourished children. A total of 26 children suffering from severe protein-calorie malnutrition were selected for the study. Serum immunoglobulins were estimated in these subjects and to assess cell-mediated immunity, enumeration of T lymphocytes and the lymphocyte proliferative response were carried out. The results show an increase in the cell-mediated immunity response in the levamisole-treated group, thereby suggesting that levamisole may help to speed the recovery of malnourished children suffering from various infections.


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