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Journal of Tropical Pediatrics 1997 43(6):366-367; doi:10.1093/tropej/43.6.366
© 1997 by Oxford University Press
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brief-report

Plasma Interleukin-3 (IL-3) and IL-7 Concentrations in Children with Homozygous Beta-thalassemia

Necil Kutukculer, MD, Canan Vergin, MD, Nazan Cetingul, MD, Kaan Kavakli, MD, Suat Caglayan, MD, Senay Oztop, MD and Gungor Nisli, MD

Ege University, The Medical School, Department of Pediatrics Izmir, Turkey

Plasma levels of IL-3 and IL-7 were studied in 23 patients with homozygous beta-thalassemia in order to determine whether these cytokines are involved in abnormalities in erythropoiesis and immune responses as observed in thalassemic patients. No significant difference was found in plasma IL-7 concentrations between thalassemic patients and healthy controls and it was suggested that IL-7 is not a cytokine involved in cellular immunological alterations in beta-thalassemia. However, the number of thalassemic patients with detectable IL-3 concentrations was significantly higher. It was concluded that IL-3 production has to be studied in detail in order to learn more about the involvement of this cytokine in erythropoiesis of thalassemic patients.


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