Skip Navigation

Journal of Tropical Pediatrics 1997 43(5):267-274; doi:10.1093/tropej/43.5.267
© 1997 by Oxford University Press
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Adah, M. I.
Right arrow Articles by Werchau, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adah, M. I.
Right arrow Articles by Werchau, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

research-article

Further Characterization of Field Strains of Rotavirus from Nigeria VP4 Genotype P6 Most Frequently Identified Among Symptomatically Infected Children

M. I. Adah*,, A. Rohwedder*, O. D. Olaleye**, O. A. Durojaiye*** {dagger} and H. Werchau*

*Institute of Medical Microbiology and Virology, Ruhr-Universität, Universitätsstr 150, 44801 Bochum, Germany
**Department of Virology, University College Hospital, College of Medicine, University of Ibadan Nigeria
***Department of Veterinary Microbiology and Parasitology, University of Ibadan Nigeria

Correspondence: M. I. Adah, Institute of Medical Microbiology and Virology, Ruhr-Universität, Universitätsstr. 150, 44801 Bochum, Germany

Polymerase chain reaction was utilized to characterize the VP4 types of 39 Rotavirus field isolates from symptomatically infected children in Nigeria. Genotype P6 was identified most frequently, occurring in 41.03 per cent of the typed specimens. Genotype P8 was identified as the next most prevalent (33.3% per cent). Genotype p6 was widespread (68.75 per cent) among infected neonates in Southern Nigeria, but mix infection was more prevalent (70 per cent) among Northern Nigerian children. Four distinct strains were identified with four different P genotypes. Overall strain G1P8 predominated (22.22 per cent) followed by G3P6 (17.8 per cent). Strain G1P8 was most prevalent (70 per cent) among infants aged 3.1–9 months, but strain G3P6 was most frequently identified among neonates ≤3 months (50 per cent). While strain G1P8 was circulating across the country at this time, strain G3P6 was regionally most identified (77.8 per cent) in Southern Nigeria. The presence of untypeable VP4 gene in Nigeria was demonstrated. The occurance of mix infection genotype demonstrates the potential for reassortment events among different rotavirus genogroups in Nigeria. The epidemlological implications of these findings for rotavirus vaccine development and application in the country were discussed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
B. S. Min, Y. J. Noh, J. H. Shin, S. Y. Baek, J. O. Kim, K. I. Min, S. R. Ryu, B. G. Kim, D. K. Kim, S. H. Lee, et al.
Surveillance Study (2000 to 2001) of G- and P-Type Human Rotaviruses Circulating in South Korea
J. Clin. Microbiol., September 1, 2004; 42(9): 4297 - 4299.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
M. I. Adah, S. Nagashima, M. Wakuda, and K. Taniguchi
Close Relationship between G8-Serotype Bovine and Human Rotaviruses Isolated in Nigeria
J. Clin. Microbiol., August 1, 2003; 41(8): 3945 - 3950.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
Z.-Y. Fang, H. Yang, J. Qi, J. Zhang, L.-W. Sun, J.-Y. Tang, L. Ma, Z.-Q. Du, A.-h. He, J.-P. Xie, et al.
Diversity of Rotavirus Strains among Children with Acute Diarrhea in China: 1998-2000 Surveillance Study
J. Clin. Microbiol., May 1, 2002; 40(5): 1875 - 1878.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
M. I. Adah, A. Wade, and K. Taniguchi
Molecular Epidemiology of Rotaviruses in Nigeria: Detection of Unusual Strains with G2P[6] and G8P[1] Specificities
J. Clin. Microbiol., November 1, 2001; 39(11): 3969 - 3975.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
N. A. Cunliffe, J. S. Gondwe, S. M. Graham, B. D. M. Thindwa, W. Dove, R. L. Broadhead, M. E. Molyneux, and C. A. Hart
Rotavirus Strain Diversity in Blantyre, Malawi, from 1997 to 1999
J. Clin. Microbiol., March 1, 2001; 39(3): 836 - 843.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.