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Journal of Tropical Pediatrics 1997 43(4):236-241; doi:10.1093/tropej/43.4.236
© 1997 by Oxford University Press
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brief-report

Growth Hormone Secretion and Serum Insulin-like Growth Factor-I Concentration in X-linked Hypophosphatemic Rickets Before and After Treatment

Ashraf T. Soliman, MD and Issa AlSalmi, MD

Departments of Pediatrics and Endocrinology, Royal Hospital P.O. Box 1331, Muscat 111, Oman

The aetiology of growth retardation in children with X-linked hypophosphatemic rickets (HPR) has not been totally defined. We evaluated growth hormone (GH)/insulin-like growth factor-I (IGF-I) changes in relation to linear growth and biochemical parameters in seven children with X-linked hypophosphatemic rickets before and after treatment with 1,25-dihydroxyvitamlnD3 and phosphate therapy for a year or more. Moreover, we compared patients' growth data and GH/IGF-I changes with those for 20 age-matched children with normal variant short stature (NVSS) [with normal GH secretion and height standard deviation score (HtSDS) before –2]. Before treatment, all children with HPR secreted normal GH in response to clonidine provocation (>10µg/l) and their IGF-I concentration was significantly lower than those with NVSS. The HtSDS and growth velocity (GV) of children with HPR improved significantly after (–3.05, 8.9 cm/year, respectively) v. before (–3.9 and 4.1 cm/year, respectively) therapy. Their serum IGF-I concentration increased significantly from 76.7 ng/ml before to 99.6 ng/ml after treatment In summary children with HPR had no abnormality of GH secretion but improvement of their linear growth was associated with significant increase of circulating IGF-I concentration after treatment.


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