Skip Navigation

Journal of Tropical Pediatrics 1997 43(1):33-37; doi:10.1093/tropej/43.1.33
© 1997 by Oxford University Press
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mishra, O. P.
Right arrow Articles by Usha,
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mishra, O. P.
Right arrow Articles by Usha,
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

research-article

Adenosine Deaminase Activity in Nephrotic Syndrome

O. P. Mishra, MD, Rajiv Garg, MBBS, Z. Ali, PhD* and Usha, MD**

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University Varanasi-221 005, India
*Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University Varanasi-221 005, India
**Department of Pathology, Institute of Medical Sciences, Banaras Hindu University Varanasi-221 005, India

Address for correspondence: Dr O. P. Mishra, 6, Rashminagar Colony, P.O.-B.H.U., Varanasi-221005, India

Cell-mediated immunity (CMI) was evaluated in 40 children with idiopathic nephrotic syndrome and 20 healthy controls. The significantly decreased response to purified protein derivative (PPD)(P<0.001), absolute lymophocyte count (ALC) (P<0.02), T-lymphocytes percentage (P<0.001) and elevated serum adenosine deaminase (ADA) activity (P<0.001) were observed in patients with active nephrotic syndrome (ANS) in comparison to controls. The overall mean values of T-lymphocytes percentage and ADA activity in ANS patients were 73.7 and 213.7 per cent of normal mean, respectively. A significant negative correlation was observed between the two parameters (r=–0.5649, P<0.001). In remission, the ALC and T-lymphocytes percentage showed significant increase in levels in comparison to their corresponding ANS values (P<0.05 and P<0.001, respectively), but the latter remained significantly lower when compared with controls (P<0.001). The ADA activity did not differ significantly in comparison to corresponding ANS level. Thus, impaired CMI was observed both in active, as well as in remission stage of the disease and ADA activity demonstrated a more pronounced change than other parameters.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.