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Journal of Tropical Pediatrics 1996 42(6):348-351; doi:10.1093/tropej/42.6.348
© 1996 by Oxford University Press
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Congenital Hypothyroidism: Increased Incidence in Najran Province, Saudi Arabia

Nasir A. M. Al-Jurayyan, FRCPC, FAAP*,, Fouad I. Shaheen, MD, DCH**, Abdulrahman A. Al-Nuaim, FRCPC, FACP*, Mahmoud I. El-Desouki, FRCPC, ABNM*, Abdulmotte Faiz, BSc**, Abdullah S. Al Herbish, FRCPC, FAAP*, Abdullah M. Abo Bakr, MsEd, FRCPC*, Abdulrahman A. Al-Swailem, FRCPE*** and Yaqoub Y. Al Mazrou, PhD, FRCGP***

*College of Medicine, King Saud University Riyadh, Saudi Arabia
**Najran General Hospital Najran, Saudi Arabia
***Ministry of Health Riyadh, Saudi Arabia

Address for correspondence: Dr Nasir A. M. Al Jurayyan, Department of Paediatrics (39), College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia. Tel.: 966-1-467-1503; Fax: 966-1-467-9463

Neonatal screening for congenital hypothyroidism using cord serum thyroid-stimulating hormone (TSH) was initiated in Najran health region in September 1990. A total of 30810 newborn infants were screened by April 1995. Of the 24 infants with abnormal thyroid function tests on recall, 22 had permanent primary congenital hypothyroidism (incidence; 1:1400) and in two male siblings transient congenital hypothyroidism (incidence; 1:15400) was proved on follow-up. There was a significantly higher incidence of dyshormonogenesis. Eight (57 per cent) of the 14 infants who were adequately studied thyroid scan revealed eutopic glands with Increased 99mTc uptake, while thyroid ectopy and aplasia were present only in three (22 per cent) infants each. Furthermore, goiter was evident clinically in two other patients.


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O. O. Ogunkeye, A. I. Roluga, and F. A. Khan
Resetting the Detection Level of Cord Blood Thyroid Stimulating Hormone (TSH) for the Diagnosis of Congenital Hypothyroidism
J Trop Pediatr, February 1, 2008; 54(1): 74 - 77.
[Abstract] [Full Text] [PDF]


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