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Journal of Tropical Pediatrics 1996 42(3):162-165; doi:10.1093/tropej/42.3.162
© 1996 by Oxford University Press
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Lactobacillus GG and Acute Diarrhoea in Young Children in the Tropics

A. R. Pant, MB BS*, S. M. Graham, FRACP*,, S. J. Allen, MD, MRCP*, S. Harikul, MD**, A. Sabchareon, MD**, L. Cuevas*, M Trop Med and C. A. Hart, FRCPath***

*Tropical Child Health Group, Liverpool School of Tropical Medicine Liverpool, UK
**Department of Tropical Pediatrics, Mahidol University Bangkok, Thailand
***Medical Microbiology, University of Liverpool Liverpool, UK

Correspondence: Dr S. M. Graham, Tropical Child Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK

A prospective, placebo controlled, triple blind clinical trial was undertaken in Thailand to determine the effect of Lactobacillus GG on recovery from acute diarrhoea in children. Thirty-nine children (mean age=8 months) were enrolled and following rehydration received either oral Lactobacillus GG (n=20) as a freeze-dried preparation or placebo (n=19) twice daily for 2 days. The clinical characteristics of the study groups were similar. There was no significant difference overall in clinical response detected between the study groups. When only those with acute non-bloody diarrhoea (n=26) were considered, the mean duration of diarrhoea was significantly shorter in the lactobacillus group (1.9 days) than in the placebo group (3.3 days) (P<0.055). Stool frequency was less on the second day in the lactobacillus group (P<0.05). The results suggest thatLactobacillus GG accelerates recovery from acute watery diarrhoea in young children in a tropical setting.


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