Skip Navigation

Journal of Tropical Pediatrics 1995 41(4):202-205; doi:10.1093/tropej/41.4.202
© 1995 by Oxford University Press
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by El-Hazmi, M. A. F.
Right arrow Articles by Bahakim, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by El-Hazmi, M. A. F.
Right arrow Articles by Bahakim, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

research-article

Red Cell Genetic Disorders and Plasma Lipids

Mohsen A. F. El-Hazmi*,, Arjumand S. Warsy**, Abdulrahman Al-Swailem***, Abdulmohsen Al-Swailem*** and Hassan Bahakim*

*College of Medicine, King Saud University Riyadh, Saudi Arabia
**College of Science, King Saud University Riyadh, Saudi Arabia
***Ministry of Health Riyadh, Saudi Arabia

Correspondence: Professor Dr Mohsen A. F. El-Hazmi, Medical Biochemistry Department (30) & W.H.O. Collaborating Centre for Haemoglobinopathies, Thalassaemias and Enzymopathies, College of Medicine & King Khalid University Hospital, P.O. Box 2925, Riyadh, Saudi Arabia

To study the plasma lipid levels in patients with red cell genetic disorders, we investigated 400 normal individuals, 100 sickle cell disease (SCD) patients, 220 sickle cell heterozygotes (Hb AS), and 100 individuals suffering from glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Whole blood samples were used for the determination of haematological parameters and red cell indices, and plasma was used for the estimation of plasma lipids using Autoanalyser American Monitor ‘Parallel’. Haemoglobin types in the haemolysates were separated by electrophoresis and G-6-PD activity was determined using kits from Boehringer Mannheim GmbH. The results from males and females were analysed separately. In each group cholesterol levels were slightly higher in the male population, while the reverse was true for triglyceride. Sickle cell disease patients had significantly (P < 0.05) lower cholesterol level compared to the normal individuals. In the Hb AS and G-6-PD deficient groups no significant differences were encountered. Multiple regression analysis between cholesterol and haematological parameters showed a statistically significant positive correlation (P < 0.01) between plasma cholesterol and total haemoglobin in each group, particularly in the sickle cell disease patients.

The results suggest that increased utilization or decreased production may account for the lower cholesterol level in severely anaemic patients, particularly those with sickle cell anaemia.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.