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Journal of Tropical Pediatrics 1994 40(4):194-197; doi:10.1093/tropej/40.4.194
© 1994 by Oxford University Press
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Risk Factors Associated with Hearing Loss in Term Neonates with Hyperbilirubinaemia

N. Y. Boo, FRCP (Edin & Glasg)*, M. Oakes, MSc**, M. S. Lye, MBBS, MPH, DR PH*** and H. Said, FRCS (Edin & Glasg)**

*Pediatrics Faculty of Medicine, National University of Malaysia Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
**Otorhinolaryngology, Faculty of Medicine, National University of Malaysia Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
***Department of Biostatistics and Epidemiology, Institute of Medical Research Kuala Lumpur, Malaysia

A study of 128 jaundiced term neonates showed that 28 (22 per cent) had hearing loss based on brain stem-evoked response. There was no significant difference in the percentage of neonates with hearing loss between those with peak serum bilirubin levels of less than 340 µmol/l (16 per cent) and those with hyperbilirubinaemia >339 µmol/l (33 per cent) (P=0.11). Logistic regression analysis showed that severe jaundice which required exchange transfusion and earlier age of onset of hyperbilirubinaemia were statistically significant risk factors associated with hearing loss (P = 0.038 and P=0.012, respectively).


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S. Ip, M. Chung, J. Kulig, R. O'Brien, R. Sege, S. Glicken, M. J. Maisels, J. Lau, and Subcommittee on Hyperbilirubinemia
An Evidence-Based Review of Important Issues Concerning Neonatal Hyperbilirubinemia
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