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Journal of Tropical Pediatrics 1994 40(2):104-107; doi:10.1093/tropej/40.2.104
© 1994 by Oxford University Press
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Female Children Respond to Recombinant Hepatitis B Vaccine with a Higher Titre than Male

Jane W. S. Fang, MRCP*, C. L. Lai, FRCP, H. T. Chung, MRCP, P. C. Wu, FRCPath** and Johnson Y. N. Lau, MD*,

*Departments of Medicine Queen Mary Hospital, Hong Kong
**Department of Pathology, University of Hong Kong Queen Mary Hospital, Hong Kong

Correspondence: Johnson Y. N. Lau, M.D., Section of Hepatobiliary Diseases, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, PO Box 100214 JHMHC, Gainesville, FL 32610, USA.

One-hundred and eighty Chinese children [age range 5 months to 12 years, seronegative for all hepatitis B vims (HBV) markers] of parents seropositive for HBV surface antigen (HBsAg) were randomized to receive doses of either 10 or 20 µg of recombinant yeast-derived HBV vaccine at intervals of 0, 1, and 6 months. Six children defaulted and three other children (1.7 per cent) seroconverted to aoti-HBc positivity without detectable HBsAg in the serum. All other children attained an anti-HBs titre of > 10 mlU/ml after three doses. Both 10 and 20 µG/dose regime gare a similar geometric mean titre (GMT) of anti-HBs. Children aged 0–4 responded with a similar titre compared with children aged <4. Female children responded with a significantly higher GMT than male children and this was due to a high proportion of female children with higher peak titres. No major side-effects were encountered. We conclude that recombinant HB vaccine is highly immunogenic, well tolerated and equally effective with doses of both 10 and 20 µg and that girls responded with a higher anti-HBs titre compared with boys.


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