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Journal of Tropical Pediatrics 1993 39(6):361-364; doi:10.1093/tropej/39.6.361
© 1993 by Oxford University Press
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Short Course Chemotherapy for Tuberculosis in Children

R. Padmini, S. Srinivasan, P. Nalini and S. Mahadevan

Departments of Pediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry 605 006, India

Correspondence: Dr S. Srinivasan, Professor of Pediatrics, JIPMER, Pondicherry 605 006, India

In order to determine the efficacy of short course chemotherapy (SCC) for tuberculosis in children, 83 newly diagnosed cases in children <12 years old were given SCC and were prospectively followed for 1–3 years. Seventy-one cases were treated for 6–9 months as they had mild to moderate involvement. Twelve cases were treated for 12 months as they had meningitis (7), disseminated tuberculosis (2), or miliary tuberculosis (3). The results showed that none of the children, at the end of follow up, showed evidence of active tuberculosis. All children tolerated the drugs well, with side effects noticed being mild, namely transient hepatitis (4), vomiting (1), and skin rash (1). It is suggested that SCC for 6–9 months using isoniazid (INH) and rifampicin along with other drugs when necessary is highly effective in most cases of tuberculosis in children and has several advantages over conventional chemotherapy of 18 months or longer duration.


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N. Kiper, A. Goccmen, E. Dilber, and U. OzGelik
Effectiveness of Short-Course, Intermittent Chemotherapy for Tuberculosis in Young Infants Aged Less Than 6 Months
Clinical Pediatrics, July 1, 1998; 37(7): 433 - 436.
[Abstract] [PDF]


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