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Gender Differences and Low Birth Weight With Maternal Smokeless Tobacco Use in Pregnancy
National Cancer Registry Project (ICMR) 9th Floor, Tata Memorial Hospital Annexe, Bombay 400 012, India
1Correspondence: Dr S. Krishnamurthy, D-7, ICMR Quarters, 25, ARG Thadani Marg, Bombay - 400 025 India
A preliminary study of maternal smokeless tobacco use, mostly oral applications of burnt tobacco or mishri, in pregnancy showed 65 of 178 singleton liveborns occurred to users and 113 to non-users in Bombay, India. Eighty-three newborns, 42 to maternal tobacco users and 41 to non-users were <2.5 kg birth weight, i.e. low birth weight (LBW; odds ratio 3.2; confidence interval 1.56.9; P<0.001). Stratifying by gender yielded odds ratios of 1.6 (P>0.1, NS) for male and 6.96 (confidence interval 2.519.4, P<0.0005), for female newborns compared to normal birthweight boys and girls, respectively. Male:female newborns were 80.6:100 in maternal tobacco users compared to 105.5:100 in non-users. Defining LBW as <2.0 kg yielded an odds ratio of 5.4 (confidence interval 1.815.2, P<0.005) in maternal tobacco users' offspring. For babies weighing 22.5 kg at birth it was 2.76 (confidence interval 1.45.5, P<0.01). Maternal use of mishri tobacco in pregnancy may be associated with (1) the offsprings' low birth weight, (2) low birth weights in girls more than in boys; (3) decreased male:female ratio in live newborns, and (4) low birth weight of <2.0 kg more than of 22.5 kg. Studies are needed to substantiate these findings. Gender differences in outcome suggest the in utero effect of maternal smokeless tobacco use on male and female fetuses may differ.
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