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Journal of Tropical Pediatrics 1993 39(4):251-252; doi:10.1093/tropej/39.4.251
© 1993 by Oxford University Press
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Haemoglobin F and A2in Nigerian Children with Sickle Cell Anaemia

O. J. Fatunde, Senior Registrar and A. B. Scott-Emuakpor, Consultant Paediatrician

Department of Child Health, University of Benin Teaching Hospital Benin City, Nigeria

Correspondence: Dr O. J. Fatunde, Department of Paediatrics, University College Hospital, Ibadan, Nigeria

The concentration of haemoglobins F and A2 in 132 Hb SS children aged 6 months to 16 years and 50 age-and sex-matched controls has been determined. The mean HbF concentration in Hb SS patients and controls were 9.5 per cent (range 1.7–24.5 per cent) and 1.5 per cent (range 0.5–14.4 per cent) respectively while HbA2 concentrations were 2.7 per cent (range 1.6–3.7 per cent) and 2.4 per cent (range 1.3–3.9 per cent) respectively. For 18 Hb SS patients seen in the stable state and during vaso-occlusive crisis, there was no significant difference in HbF concentration between the two states.


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