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Journal of Tropical Pediatrics 1993 39(4):243-250; doi:10.1093/tropej/39.4.243
© 1993 by Oxford University Press
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Role of Transfusion-mediated Viral Infections on the Lymphocyte Subset Profile in Multi-transfused Children

Sangita Yadav, MD*,, Debashish Chattopadhya, MD**, Charu Prakash, MD**, Sudershan Kumari, MD* and T. Vergheese, MD**

*Department of Paediatrics, Kalawati Saran Children's Hospital Delhi, India
**Institute of Communicable Diseases Delhi, India

Correspondence: Dr Sangita Yadav, Department of Paediatrics, Maulana Azad Medical College, New Delhi-110002, India

A total of 74 multitransfused (MT) children of beta thalassaemia major were analysed for prevalent viral markers transmitted through transfusion. A higher incidence of serologcal markers for Hepatitis B virus (HBV), cytomegalovirus (CMV) could be observed in the group of MT children compared to control group. There was a significant trend ({chi}2=33.4; P<0.001) in the increase in prevalence of viral markers along with the increase in the number of transfusions. MT children receiving more than 50 transfusions were found to have evidence for at least one or multiple viral infections transmitted through blood. Children receiving more than 50 transfusions were characterized by marked alteration of T3, T8 and B cells while T4/T8( ratio was found to be significantly decreased (P < 0.001) only in the group of children receiving more than 100 transfusions. Relative assessment of the alteration of lymphocyte subsets in various groups of viral infection showed that cases with CMV IgM to have more marked influence on the alteration of T8, cells, T4/8, ratio, and B cells compared to other groups of viral infections. Reassessment of the lymphocyte subset profile in MT children in the light of CMV IgM positive cases revealed that in children receiving more than 50 transfusions significant alterations of lymphocyte subjects were influenced by the presence of CMV lgM positive cases in these groups. Our study points out that the correlation between the alteration of lymphocyte subset profile and number of transfusion in MT children need to be reassessed in the light of acute CMV infection in the form of CMV IgM.


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