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Journal of Tropical Pediatrics 1993 39(1):30-31; doi:10.1093/tropej/39.1.30
© 1993 by Oxford University Press
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Cortisol Levels in Children with Haemoglobinopathies in North Jordan

Nabil Bashir*,, Abdel Fattah Al-Hader** and Labib Al-Shareef***

*Department of Biochemistry, Jordan University of Science and Technology Irbid-Jordan
**Department of Physiology and Jordan University of Science and Technology Irbid-Jordan
***Department of Public Health, Faculty of Medicine, Jordan University of Science and Technology Irbid-Jordan

Correspondence: Dr Nabil Bashir, Department of Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid-Jordan

Serum cortisol levels of 100 children 3–10 years old with various haemoglobinopathies were measured. The mean cortisol levels of sickle cell trait, sickle cell disease, ß-thalassemia minor and {alpha}2-thalassemia were significantly (P<0.05) lower than those of normal subjects. The decrease in cortisol levels varied from 25 (in the sickle cell trait group) to 57 per cent (in the {alpha}2-thalassemia group) of the mean cortisol levels of the control group. These results suggest the presence of hypoadrenalism and its possible association with the indicated haemoglobinopathies.


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