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Journal of Tropical Pediatrics 1990 36(5):213-217; doi:10.1093/tropej/36.5.213
© 1990 by Oxford University Press
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Cerebrospinal Fluid C-Reactive Protein Measurement—A Bedside Test in the Rapid Diagnosis of Bacterial Meningitis

M. John*, I. S. Raj*, R. Macaden*, T. S. Raghuveer**, M. Yeswanth** and D. M. Meundi***

*Department of Microbiology, St. John's Medical College Bangalore 560034, Karnataka, India
**Department of Pediatrics, St. John's Medical College Hospital Bangalore 560034, Karnataka, India
***Department of Pediatrics, Vani Vilas Hospital Bangalore 560002, Karnataka, India

C-reactive protein (C-RP) determinations were performed by the Latex agglutination method on the cerebrospinal fluid (CSF) samples of 212 patients with clinical features suggestive of meningitis. Patients were grouped as follows

Group I: bacterial meningitis and partially treated bacterial meningitis (n = 22).
Group II: viral encephalitis (n = 11).
Group III: tuberculous meningitis (n = 18).
Group IV: (i) febrile convulsions (n = 87); (ii) epileptic seizures (n = 70); (iii) intracranial haemorrhage (n = 4).

C-RP was a better indicator of bacterial meningitis (sensitivity 91 per cent) than the Gram's stain (sensitivity 46 per cent). C-RP was positive in 91 per cent of palienis in Group I, none in Groups II and III and 0.6 per cent in Group IV. C-RP determination in CSF proved to be a useful indicator of bacterial meningitis and served to distinguish it from viral encephalitis, tuberculous meningitis, febrile convulsions and other central nervous system disorders.


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