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Journal of Tropical Pediatrics 1989 35(4):175-178; doi:10.1093/tropej/35.4.175
© 1989 by Oxford University Press
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Cell-mediated Immune Responses in Malnourished Host

S. Fakhir, Dr, MD, DCH, P. Ahmad, Dr, MD, DCH, M. M. A. Faridi, Dr, MD, DCH and A. Rattan, Dr, MD*

Departments of Pediatrics, J.N. Medical College A.M.U., Aligarh—202001, India
*Department of Microbiology, J.N. Medical College A.M.U., Aligarh—202001, India

Correspondence: Dr (Mrs) P. Ahmad, Department of Pediatrics, J.N. Medical College, A.M.U., Aligarh-202001, India.

One hundred children in the age group 6 months to 5 years were investigated for cell-mediated immune response in relation to their nutrition. The nutritional status was assessed by the Wellcome classification. The majority (54 per cent) of children had marasmus. Absolute lymphocyte count was found to be significantly low (P<0.01) in all malnourished groups except in mild forms of undernutrition. Small lymphocytes were also found to be significantly decreased (P<0.001) in malnourished children. A significant depression (P<0.001) was observed in the percentage and absolute T cells in all the malnourished children with kwashiorkor who showed the maximum depression of counts. All the control children showed DNCB skin reactions above grade 2 + while only 39 per cent of malnourished children showed reaction of this grade. After 4—6 weeks of dietary therapy, T cell counts were comparable with control values and DNCB skin test returned to normal in more than 75 per cent of cases.


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