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Journal of Tropical Pediatrics 1989 35(1):6-9; doi:10.1093/tropej/35.1.6-a
© 1989 by Oxford University Press
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Phagocyte Metabolic Functions in Iron Deficiency Anaemia of Indian Children

S. Mustafa Hasan, DCH*, Mehar Aziz, MD (Path)**, Pervin Ahmad, DCH MD (Paed)* and Mithlesh Aggarwal, MD (Microbiol)***

*Department of Paediatrics, J. N. Medical College A.M.U. Aligarh, U.P., India
**Department of Pathology, J. N. Medical College A.M.U. Aligarh, U.P., India
***Department of Microbiology, J. N. Medical College A.M.U. Aligarh, U.P., India

Nitroblue tetrazolium test (NBT) and bactericidal activity of polymorphonuclear leucocytes was studied in 40 patients with iron deficiency anaemia (aged 0–12 years). NBT test had a significant correlation with serum iron (P< 0.001) in all cases of iron deficiency anemia. Haemoglobin levels <4g/dl also correlated significantly with NBT score. Bactericidal activity with opsonin-coated Staphylococcus aureus was considerably decreased in severe anaemia, but no significant correlation was found with serum iron concentration (P<0.1). The phagocytic and bactericidal activity of polymorphonuclear leucocytes is dependent upon serum iron levels and is considerably reduced in iron deficient state in anaemic children.


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