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Journal of Tropical Pediatrics 1988 34(6):282-288; doi:10.1093/tropej/34.6.282
© 1988 by Oxford University Press
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Undernutrition and Altered T-cell Homeostasis in Children with Severe Chest Diseases

Anura Rambukkana*, Kunal Saha*, Arvind Sahu* and Kamlesh Chopra**

* Department of Immunology, Vallabhbhai Patel Chest Institute, University of Delhi Delhi-110007, India
** Department of Paediatrics, Maulana Azad Medical College New Delhi-110002, India

Respiratory infections together with diarrhoeal diseases underlie many deaths of millions of children of the third world. This paper describes the influence of severe chest diseases, such as, bronchopneumonia, bronchiectasis, and empyema on the nutrition and cell-mediated immunity of affected children. There was almost invariably significant decrease of the levels of serum elements, e.g. zinc and iron, and serum micronutrient, e.g. vitamin A, as well as their binding proteins in the patients with empyema and in those who bad associated undernutrition. The number of T3, T4 and T8 cells were also reduced in patients who bad concomitant undernutrition. Furthermore, T4 and T8 cell homeostasis was perturbed in severely ill patients. Most significantly, T3, T4, and T8 cell markers had positive correlation with serum vitamin A and iron concentrations thereby indicating an interaction between nutrition and immunity.


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