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Journal of Tropical Pediatrics 1988 34(2):65-70; doi:10.1093/tropej/34.2.65
© 1988 by Oxford University Press
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Prognostic Evaluation of Serum Leucine Aminopeptidase in Malignancy of Lymphoreticular and Haemopoietic Cell Lines in Children, with Special Reference to Malignant Histiocytosis of the Intestine

Mehar Aziz, Subodh K. Gupta, Ansar A. Khan and A. Saluddin

Departments of Pathology and Biochemistry, J.N. Medical College and Hospital A.M.U. Aligarh-202001

Serum leucine aminopeptidase (LAP) levels were estImated in 10 patients with non-Hodgkins lymphoms, 15 patients with leukaemia, and 50 control cases in the pediatric age group. In the lymphoma group the serum enzyme levels were markedly increased In the case of histiocytic lymphomas and malignant histio cytosis of the Intestine, followed by lymphocytic lymphomas. In the leukaemia group, higher levels of serum LAP were detected in Iymphocytic leukaemla as compared to myeloid leukaemia.

Serum LAP rises steadily with clinical staging in leukaemia and lymphomas. Nevertheless, a sharp in crease was observed in stage IV specifically with hepatic infiltration. However, in histiocytic lymphomas and malignant histiocytosis of intestine, the serum LAP level remained elevated even in the absence of hepatic infiltration. Therefore, serum LAP was a specific prognostic marker for the malignancy of ‘monocyte-macrophage’ cell lines.


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