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Journal of Tropical Pediatrics 1988 34(2):59-64; doi:10.1093/tropej/34.2.59
© 1988 by Oxford University Press
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Sickle Cell Hepatic Crisis in Nigerian Children

W. N. Kaine and I. O. K. Udeozo

Departments of Paediatrics and Chemical Pathology, University of Nigeria Teaching Hopsital Enugu, Nigeria

The clinical features and laboratory findings in 38 cases of sickle cell hepatic crisis in Nigerian children have been analysed. The illness resembled a mild form of viral hepatitis in all but a few cases. Anorexia and liver tenderness were absent in over 65 per cent of the patients. Patients with grossly abnormal liver function tests did not show slgss of serious illness.

Haematological investigations revealed leucocytosis in 34(90 per cent) patients. There were numerous normoblasts In the blood film of six (16 per cent) patients. Liver histology showed dilated sinusoids con taining hypertrophled Kuppfer cells and numerous sickled red cells. There were also patchy areas of liver cell necrosis and cellular infiltration in the lobular parenchyma.

Liver failure occurred in one patient indicating that sickle cell hepatic crisis in Nigerian children is potentially dangerous.


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