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Journal of Tropical Pediatrics 1987 33(6):326-328; doi:10.1093/tropej/33.6.326
© 1987 by Oxford University Press
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An Investigation into the Iron Status of Children with Sickle-Cell Disease in Western Nigeria

L. Helen Jeyakumar*, E. O. Akpanyung*, A. A. Akenyemi** and G. O. Emerole*

*Department of Biochemistry, College of Medicine, University of Ibadan Nigeria
**Oni Memorial Children Hospital, Ring Road Ibadan, Nigeria

Plasma iron, plasma total iron binding capacity, percentage saturation of plasma transferrin, the free erythrocyte protoporphyrin (FEP) haem ratio, and haematocrit values were estimated in 24 children with sickle cell disease and in 15 children without this disease during the first decade of their lives. All the children were indigenous Nigerians. The mean values of plasma iron and the percentage saturation of plasma transferrin were lower in sicklers than in non-sicklers. The mean values of plasma total iron binding capacity and free erythrocyte protoporphyrin/haem ratio were not significantly different. The necessity to investigate the probable intrinsic causative factors of iron deficiency in sicklers in this region and periodical monitoring of the haematological, biochemical, and clinical response following the oral supplementation of iron in sickle cell disease patients with iron deficiency are suggested.


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