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Journal of Tropical Pediatrics 1987 33(2):75-77; doi:10.1093/tropej/33.2.75
© 1987 by Oxford University Press
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Cytomegalovirus Antibodies in Breast Milk and Sera of Mother-infant Pairs

O. O. Kassim, PhD, MPH, O. Afolabi, PhD, K. A. Ako-Nai, PhD, S. E. A. Torimiro, MD, G. K. Littleton, PhD, O. O. Oke, PhD and F. E. Grissom, PhD

Departments of Microbiology, and Physiology and Biophysics, Howard University College of Medicine Washington DC Departments of Chemistry and Pediatrics, University of Ife Ile-Ife, Nigeria

Correspondence: Dr O. O. Kassim, Department of Microbiology, Howard University College of Medicine, 520 W Street NW, Washington DC, 20059, USA.

Maternal breast milk samples and sera from 33 Nigerian mother-infant pairs were examined for the prevalence and concentrations of total IgG, IgM, and IgA immunoglobulins, and for specific IgG anti-bodies to cytomegalovirus (CMV). The mean total IgG concentration was 2727 mg/dl for maternal sera, 669 mg/dl for infant sera and 55 mg/dl for the breast milk. While a significant proportion (55 per cent) lacked measurable titres of IgM, all the milk samples carried modest concentrations of IgA. Thirty (91 per cent) of the 33 mothers were seropositive for CMV, compared to 33 per cent of the infants. All the CMV positive milk and infant sera came from seropositive mothers, while 63 per cent of seronegative infants came from CMV positive mothers.


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