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Journal of Tropical Pediatrics 1974 20(3):135-140; doi:10.1093/tropej/20.3.135
© 1974 by Oxford University Press
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Epidemiologic Assessment of a Nationwide Multiple Antigen Vaccine Campaign

PHILIP J. LANDRIGAN, M.D., Medical Epidemiologist, EDUARDO NAVARRO RIVAS, M.D., Director and DONALD L. EDDINS, B.S., Chief

Smallpox Eradication Programme, Centre for Disease Control Atlanta, Georgia 30333
Division de Epidemiologia, Dirección General de Salud, Ministerio de Salud Pública y Asistencia Social República de El Salvador
Statistical Activity, Immunization Branch, State and Community Services Division, Centre for Disease Control Atlanta, Georgia 30333

Determination of immunity levels in a population before and after a vaccine campaign provides an objective measure of the campaign's effectiveness. A nationwide, two-stage, multiple-antigen vaccine programme in El Salvador was assessed by measuring prevalence of measles HI antibody before and after the first cycle (which included measles, DPT, and TOPV) and by determining the BCG scar rate before and after the second cycle (BCG, DPT, and TOPV). In the pre-campaign assessment measles antibodies were noted in 50 per cent of urban children by age 15 months, and in half of rural children by 28 months. Measles antibody prevalence in 12 to 60-month-old children was increased by the campaign from 58.7 per cent to 87.3 per cent; the seroconversion rate was at least 86.6 per cent. BCG scar prevalence increased from 18.1 per cent to 72.6 per cent. Future campaigns should focus on children 9 to 24 months of age, should occur most often in urban areas, and should continue the practice of objective assessment.


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